Basic Information
| LncRNA/CircRNA Name | ANRIL |
| Synonyms | Antisense non-coding RNA in the INK4A locus |
| Region | GRCh38_9:21994778-22121097 |
| Ensemble | ENSG00000240498 |
| Refseq | NR_003529 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qRT-PCR, Western blotting, Luciferase reporter analysis, RIP |
| Sample | HCC paraffin-embedded tissue samples,HCC tumorigenic line Huh7, SMMC7721, HepG2, Hep3B, and normal hepatic cell line L02 |
| Expression Pattern | up-regulated |
| Function Description | lncRAN ANRIL expression was significantly increased in HCC tissues or cells compared with the normal adjacent tissues and normal tissues or cells.overexpression of lncRNA ANRIL promoted mitochondrial function in HCC cells, evident by the increased mitochondrial DNA copy numbers, ATP (Adenosine triphosphate) level, mitochondrial membrane potential, and the expression levels of mitochondrial markers, while ANRIL knockdown exerted the opposite effects.lncRNA ANRIL acted as a competing endogenous RNA to increase ARL2 (ADP-ribosylationfactor-like 2) expression via sponging miR-199a-5p. |
| Pubmed ID | 31670868 |
| Year | 2020 |
| Title | Long Non-Coding RNA ANRIL Enhances Mitochondrial Function of Hepatocellular Carcinoma by Regulating the MiR-199a-5p/ARL2 Axis |
External Links
| Links for ANRIL | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |