Basic Information
| LncRNA/CircRNA Name | JPX |
| Synonyms | JPX, DCBALD06, ENOX, LINC00183, NCRNA00183 |
| Region | GRCh38_X:73944184-74070408 |
| Ensemble | ENSG00000225470 |
| Refseq | NR_024582 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, Dual luciferase reporter assay |
| Sample | hepatocellular carcinoma tissues, cell line HepG2 |
| Expression Pattern | down-regulated |
| Function Description | JPX and XIST expression was significantly decreased in HCC pathologic specimens.miR-155-5p is regulated by a JPX/XIST axis. Cell proliferation and apoptosis assay revealed that overexpression of JPX significantly decreased cell proliferation, but increased apoptosis in HepG2 cells, which was abolished by either XIST knockdown or by miR-155-5p mimic transfection. |
| Pubmed ID | 30091314 |
| Year | 2018 |
| Title | XIST Induced by JPX Suppresses Hepatocellular Carcinoma by Sponging miR-155-5p. |
External Links
| Links for JPX | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |