Basic Information
| LncRNA/CircRNA Name | JPX |
| Synonyms | JPX, DCBALD06, ENOX, LINC00183, NCRNA00183 |
| Region | GRCh38_X:73944184-74070408 |
| Ensemble | ENSG00000225470 |
| Refseq | NR_024582 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung cancer |
| ICD-0-3 | C34 |
| Methods | RT-qPCR, Luciferase reporter assay, western blotting |
| Sample | lung cancer tissues,human normal bronchial epithelial cell (BEAS-2B) and 4 human lung adenocarcinoma cells (SPC-A-1, LTEP-a-2, A549, NCI-H1299) |
| Expression Pattern | up-regulated |
| Function Description | We observed that lncRNA JPX was upregulated in lung cancer metastatic tissues and was closely correlated with tumor size and an advanced stage. Functionally, JPX promoted lung cancer cell proliferation in vitro and facilitated lung tumor growth in vivo. Additionally, JPX upregulated Twist1 by competitively sponging miR-33a-5p and subsequently induced EMT and lung cancer cell invasion. Interestingly, JPX and Twist1 were coordinately upregulated in lung cancer tissues and cells. Mechanically, the JPX/miR-33a-5p/Twist1 axis participated in EMT progression by activating Wnt/?-catenin signaling. |
| Pubmed ID | 31941509 |
| Year | 2020 |
| Title | lncRNA JPX/miR-33a-5p/Twist1 Axis Regulates Tumorigenesis and Metastasis of Lung Cancer by Activating Wnt/?-catenin Signaling |
External Links
| Links for JPX | GenBank HGNC NONCODE |
| Links for lung cancer | OMIM COSMIC |