Basic Information
| LncRNA/CircRNA Name | ITGB2-AS1 |
| Synonyms | NA |
| Region | GRCh38_21:44921051-44929678 |
| Ensemble | ENSG00000227039 |
| Refseq | NR_038311 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | Western blot, Flow cytometry, etc. |
| Sample | cell lines (MDA-MB-231, MCF-7) |
| Expression Pattern | down-regulated |
| Function Description | The results of biological function experiments showed that ITGB2-AS1 could promote the migration and invasion of breast cancer. Furthermore, ITGB2-AS1 increased the mRNA and protein expression of ITGB2. LncRNA ITGB2-AS1 could promote the migration and invasion of breast cancer cells by up-regulating ITGB2.higher expression group had a poorer overall survival rate. |
| Pubmed ID | 29941860 |
| Year | 2018 |
| Title | LncRNA ITGB2-AS1 Could Promote the Migration and Invasion of Breast Cancer Cells through Up-Regulating ITGB2. |
External Links
| Links for ITGB2-AS1 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |