Basic Information
| LncRNA/CircRNA Name | IRF1-AS |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | esophageal squamous cell carcinoma |
| ICD-0-3 | NA |
| Methods | qRT-PCR , Luciferase reporter assay , RIP , RNAi RNA-seq , Western blot etc. |
| Sample | ESCC tissues ,adjacent normal tissues ,ESCC cell lines,Het-1A esophageal epithelial cells |
| Expression Pattern | down-regulated |
| Function Description | IFN-inducible nuclear lncRNA IRF1-AS was positively correlated with IRF1 expression. IFNs upregulate IRF1-AS via the JAK-STAT pathway.IRF1-AS inhibits oesophageal squamous cell carcinoma (ESCC) proliferation and promotes apoptosis in vitro and in vivo. IRF1-AS activates IRF1 transcription through interacting with ILF3 and DHX9.In turn, IRF1 binds to the IRF1-AS promoter directly and activates IRF1-AS transcription. IRF1-AS activates the IFN response in vitro and in vivo.Furthermore, IRF1-AS was downregulated in ESCC tissues, and low expression correlated with poor prognosis. |
| Pubmed ID | 31173852 |
| Year | 2019 |
| Title | Interferon-inducible lncRNA IRF1-AS Represses Esophageal Squamous Cell Carcinoma by Promoting Interferon Response |
External Links
| Links for IRF1-AS | GenBank HGNC NONCODE |
| Links for esophageal squamous cell carcinoma | OMIM COSMIC |