Basic Information
| LncRNA/CircRNA Name | ANRIL |
| Synonyms | antisense non-coding RNA in the INK4 locus |
| Region | GRCh38_9:21994778-22121097 |
| Ensemble | ENSG00000240498 |
| Refseq | NR_003529 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | acute myeloid leukemia |
| ICD-0-3 | NA |
| Methods | qRT-PCR, Dual luciferase reporter assay, Western blot analysis |
| Sample | Bone marrow samples,stromal cell line HS and leukemia cell lines HL-60 and THP-1 |
| Expression Pattern | up-regulated |
| Function Description | ANRIL was up-regulated both in the BM samples from AML patients and cell lines (HL-60 and THP-1), of which expression was negatively correlated with miR-34a expression. ANRIL knockdown inhibited cell proliferation, migration and invasion but promoted apoptosis of AML cells, while overexpression of miR-34a exerted opposite effects.ANRIL knockdown significantly inhibited the tumorigenesis of AML. |
| Pubmed ID | 31830533 |
| Year | 2020 |
| Title | LncRNA ANRIL Promotes Cell Proliferation, Migration and Invasion During Acute Myeloid Leukemia Pathogenesis via Negatively Regulating miR-34a |
External Links
| Links for ANRIL | GenBank HGNC NONCODE |
| Links for acute myeloid leukemia | OMIM COSMIC |