Basic Information
| LncRNA/CircRNA Name | IRAIN |
| Synonyms | IRAIN, IGF1R-AS |
| Region | GRCh38_15:98645863-98651221 |
| Ensemble | NA |
| Refseq | NR_126453 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR etc. |
| Sample | breast cancer tissues |
| Expression Pattern | down-regulated |
| Function Description | In breast cancer tissues, we found that IRAIN lncRNA was transcribed from an intronic promoter in an antisense diretcion as compared to the IGF1R coding mRNA. Unlike the IGF1R coding RNA, this non-coding RNA was imprinted, with monoallelic expression from the paternal allele. IRAIN was aberrantly imprinted in both tumours and peripheral blood leucocytes, exhibiting a pattern of allele-switch: the allele expressed in normal tissues was inactivated and the normally imprinted allele was expressed. |
| Pubmed ID | 25465188 |
| Year | 2014 |
| Title | Aberrant allele-switch imprinting of a novel IGF1R intragenic antisense non-coding RNA in breast cancers. |
External Links
| Links for IRAIN | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |