Basic Information
| LncRNA/CircRNA Name | IRAIN |
| Synonyms | IRAIN, IGF1R-AS |
| Region | GRCh38_15:98645863-98651221 |
| Ensemble | NA |
| Refseq | NR_126453 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | pancreatic cancer |
| ICD-0-3 | C25 |
| Methods | qPCR, RNAi, Western blot, Flow cytometry assay etc. |
| Sample | pancreatic cancer tissues |
| Expression Pattern | up-regulated |
| Function Description | We found that upregulation of lncRNA IRAIN was significantly correlated with tumor size, TNM stage, and lymph node metastasis in a cohort of 37 PC patients. Knockdown of IRAIN significantly induced cell apoptosis and inhibited cell proliferation in both BxPC-3 and PANC-1 cells. Further mechanism study showed that, by binding to histone demethylase lysine-specific demethylase 1 (LSD1), an enhancer of zeste homolog 2 (EZH2), IRAIN reduced PC tumor cell apoptosis and induced growth arrest by silencing the expression of Kruppel-like factor 2 (KLF2) and P15. |
| Pubmed ID | 27644252 |
| Year | 2016 |
| Title | Long non-coding RNA IRAIN suppresses apoptosis and promotes proliferation by binding to LSD1 and EZH2 in pancreatic cancer. |
External Links
| Links for IRAIN | GenBank HGNC NONCODE |
| Links for pancreatic cancer | OMIM COSMIC |