Basic Information
| LncRNA/CircRNA Name | ILF3-AS1 |
| Synonyms | XLOC_013222 |
| Region | GRCh38_19:10651862-10653844 |
| Ensemble | ENSG00000267100 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | melanoma |
| ICD-0-3 | NA |
| Methods | qPCR, RIP etc. |
| Sample | breast cancer tissues, non-small cell lung cancer tissues |
| Expression Pattern | up-regulated |
| Function Description | lncRNA ILF3-AS1 is upregulated in melanoma tissues and cell lines, and correlated with poor prognosis of melanoma patients. Functional experiments showed that knockdown of ILF3-AS1 inhibits melanoma cell proliferation, migration and invasion. Mechanistically, we found that ILF3-AS1 interacts with EZH2, promotes the binding of EZH2 to the miR-200b/a/429 promoter, and represses miR-200b/a/429 expression. The expression of ILF3-AS1 is negatively correlated with that of miR-200b/a/429 in melanoma tissues.Moreover,inhibition of miR-200b/a/429 abrogates the biological roles of ILF3-AS1 knockdown on melanoma cell proliferation, migration and invasion. |
| Pubmed ID | 28935763 |
| Year | 2017 |
| Title | Long noncoding RNA ILF3-AS1 promotes cell proliferation, migration and invasion via negatively regulating miR-200b/a/429 in melanoma |
External Links
| Links for ILF3-AS1 | GenBank HGNC NONCODE |
| Links for melanoma | OMIM COSMIC |