Basic Information
| LncRNA/CircRNA Name | ILF3-AS1 |
| Synonyms | XLOC_013222 |
| Region | GRCh38_19:10651862-10653844 |
| Ensemble | ENSG00000267100 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | Malignant melanoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, etc. |
| Sample | benign nevi andprimary melanoma tissues, The human epidermal melanocyte HEMa-LP, The human melanoma cell lines SK-MEL-2, SK-MEL-28, and A375 |
| Expression Pattern | up-regulated |
| Function Description | Mechanistic investigation revealed that ILF3 directly binds ILF3-AS1, increases ILF3-AS1 transcript stability, and upregulates ILF3-AS1 transcript levels. ILF3-AS1 represses the binding of EZH2 to the promoter of ILF3, induces euchromatin formation at ILF3 promoter, and activates ILF3 transcription. Thus, ILF3 and ILF3-AS1 form positive feedback loop, which induces the upregulation of ILF3 and ILF3-AS1 in melanoma. The expression of ILF3-AS1 is positively correlated with ILF3 in melanoma tissues. Functional assays revealed that overexpression of ILF3 promotes melanoma proliferation, migration, and invasion. Depletion of ILF3 inhibits melanoma proliferation, migration, and invasion. Moreover, concurrent depletion of ILF3 and ILF3-AS1 significantly suppresses melanoma proliferation, migration, and invasion. |
| Pubmed ID | 30588088 |
| Year | 2018 |
| Title | The positive feedback loop between ILF3 and lncRNA ILF3-AS1 promotes melanoma proliferation, migration, and invasion |
External Links
| Links for ILF3-AS1 | GenBank HGNC NONCODE |
| Links for Malignant melanoma | OMIM COSMIC |