Basic Information
| LncRNA/CircRNA Name | IHS |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qRT-PCR , in vitro knockdown etc. |
| Sample | HCC tissues and para-tumor tissues ,human hepatocyte LO2 and HCC cell lines (SMMC-7721, MHCC-97H, BEL-7402, PLC/PRF/5, SK-HEP-1, and HepG2) |
| Expression Pattern | up-regulated |
| Function Description | lncIHS was overexpressed in HCC and decreased the survival rate of HCC patients. Knockdown of lncIHS inhibited HCC cell migration, invasion, and proliferation, and vice versa.ncIHS positively regulated the expression of epithelial mesenchymal transition (EMT)-related markers c-Myc and Cyclin D1, as well as the activation of the ERK- and AKT-signaling pathways.llncIHS exerted its oncogenic effect through ERK and AKT signaling.ncIHS regulated multiple genes that were the upstream molecules of the ERK- and AKT-signaling pathways. |
| Pubmed ID | 31128422 |
| Year | 2019 |
| Title | A Novel lncRNA IHS Promotes Tumor Proliferation and Metastasis in HCC by Regulating the ERK- And AKT/GSK-3?-Signaling Pathways |
External Links
| Links for IHS | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |