Basic Information
| LncRNA/CircRNA Name | IGKV |
| Synonyms | IGKV2-29, A18, A18b, IGKV, IGKV229, IGVK-A18 |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | triple negative breast cancer |
| ICD-0-3 | C50 |
| Methods | Microarray, qPCR etc. |
| Sample | primary breast cancer tissues, cell lines (MDA-MB-231, HCC-1937, MDA-MB-468, MDA-MB-453 etc.) |
| Expression Pattern | down-regulated |
| Function Description | The qRT-PCR results showed that, compared with non-TNBC tissues, C17orf76-AS1 and CTC-338M12.3 were dominantly up-regulated in TNBC tissues; on the other hand, RP11-434D9.1, IGKV, LINC00052, BC016831, RP4-781K5.4, and LOC441242 were obviously down-regulated. However, there are some differences between the lncRNA expression patterns of tissues and cell lines. Briefly, compared with the non-TNBC cell group, only 4 lncRNAs (BC016831, IGKV, LINC00052, and RP11-434D9.1) were down-regulated congruously in all 4 TNBC cells. |
| Pubmed ID | 26910840 |
| Year | 2016 |
| Title | LncRNAs as new biomarkers to differentiate triple negative breast cancer from non-triple negative breast cancer. |
External Links
| Links for IGKV | GenBank HGNC NONCODE |
| Links for triple negative breast cancer | OMIM COSMIC |