Basic Information
| LncRNA/CircRNA Name | IGF2AS |
| Synonyms | IGF2-AS, IGF2-AS1, IGF2AS, PEG8 |
| Region | GRCh38_11:2140501-2148666 |
| Ensemble | ENSG00000099869 |
| Refseq | NM_016412 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, Western blot |
| Sample | cell lines (HepG2, SMMC7721, Huh7) |
| Expression Pattern | up-regulated |
| Function Description | The results demonstrated that Igf2as was upregulated in HCC cells and tissues, and that the inhibition of Igf2as using a targeted small interfering RNA (si-Igf2as), significantly decreased cell proliferation and increased apoptosis. Western blot analysis identified that the extracellular signal-regulated kinase/mitogen-activated protein kinase (ERK/MAPK) signaling pathway was inhibited in cells transfected with si-Igf2as. In addition, cell migration was markedly reduced by the knockdown of Igf2as. These results suggest that lncRNA Igf2as may control hepatocellular progression primarily through the regulation of the ERK/MAPK signaling pathway. |
| Pubmed ID | 28928822 |
| Year | 2017 |
| Title | Long non-coding RNA Igf2as controls hepatocellular carcinoma progression through the ERK/MAPK signaling pathway. |
External Links
| Links for IGF2AS | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |