Basic Information
| LncRNA/CircRNA Name | IGF2AS |
| Synonyms | IGF2-AS1, IGF2AS, PEG8 |
| Region | GRCh38_11:2140501-2148666 |
| Ensemble | ENSG00000099869 |
| Refseq | NM_016412 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | prostate cancer |
| ICD-0-3 | C61.9 |
| Methods | qPCR, other |
| Sample | PCa tissues and cell lines, VCaP, PC3, MDA/Pca/2b,DU145, NCI-H660 and LNCaP |
| Expression Pattern | down-regulated |
| Function Description | IGF2AS was downregulated in both PCa cell lines and human PCa tumors. In VCaP and PC3 cells, lentivirus-induced IGF2AS overexpression suppressed cancer cell proliferation and invasion in vitro, and xenograft development in vivo. IGF2 was downregulated by IGF2AS overexpression. Conversely, IGF2 upregulation revered the suppressing function of IGF2AS on PCa proliferation and invasion. |
| Pubmed ID | 30423304 |
| Year | 2019 |
| Title | Long Noncoding RNA IGF2AS Is Acting as an Epigenetic Tumor Suppressor in Human Prostate Cancer |
External Links
| Links for IGF2AS | GenBank HGNC NONCODE |
| Links for prostate cancer | OMIM COSMIC |