Basic Information
| LncRNA/CircRNA Name | IGF2AS |
| Synonyms | NA |
| Region | GRCh38_11:2140501-2148666 |
| Ensemble | ENSG00000099869 |
| Refseq | NM_016412 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qRT-PCR , Luciferase reporter assay , Western blot , RIP , in vitro knockdown etc. |
| Sample | GAC tissues and the corresponding para-cancer tissues,Human gastric normal epithelial mucosa cell line GES1,human GAC cell lines (BGC823, SGC7901, MGC803 and AGS) , GC cell lines (HGC27 and MKN45) |
| Expression Pattern | up-regulated |
| Function Description | IGF2-AS is up-regulated in gastric adenocarcinoma (GAC) tissues and correlated with poor prognosis in patients with GAC. Knockdown of IGF2-AS significantly suppressed cell proliferation, migration and invasion. Most IGF2-AS was distributed in the cytoplasm, suggesting that IGF2-AS functioned as a potential ceRNA.IGF2-AS functioned as an efficient miR-503 sponge and the level of miR-503 showed an inverse correlation with IGF2-AS.Moreover, IGF2-AS expression exhibited a negative correlation with miR-503 and a positive correlation with IGF2-AS. Meanwhile, up-regulation of miR-503 or down-regulation of SHOX2 decreased IGF2-AS overexpression induced promotion in proliferation and motility of cells. Knockdown of IGF2-AS significantly reduced tumor volume. |
| Pubmed ID | 31183590 |
| Year | 2019 |
| Title | IGF2-AS afects the?prognosis and?metastasis of?gastric adenocarcinoma via?acting as?a?ceRNA of?miR-503 to?regulate SHOX2 |
External Links
| Links for IGF2AS | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |