Basic Information
| LncRNA/CircRNA Name | ICR |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | autophagy0 | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | Microarray, qPCR etc. |
| Sample | HCC tissues, cell lines (CSQT-2, Huh7, Hep3B) |
| Expression Pattern | up-regulated |
| Function Description | Compared with the corresponding primary tumors, PVTT expressed different lncRNAs and mRNAs, including the up-regulated lncRNA ICR and ICAM-1. ICR regulated ICAM-1 expression by increasing the stability of its mRNA through RNA duplex formation, which modulated the CSC properties of ICAM-1+ HCC cells. ICR transcription in ICAM-1+ HCC cells was regulated by Nanog and inhibition of ICR in situ significantly reduced ICAM-1 expression and ICAM-1+ HCC cells in tumors in vivo. Moreover, elevated ICR and ICAM-1 expression in tumors was correlated with PVTT development and poor clinical outcomes |
| Pubmed ID | 26667486 |
| Year | 2015 |
| Title | ICAM-1-related non-coding RNA in cancer stem cells maintains ICAM-1 expression in Hepatocellular Carcinoma |
External Links
| Links for ICR | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |