Basic Information
| LncRNA/CircRNA Name | HULC |
| Synonyms | HULC, HCCAT1, LINC00078, NCRNA00078 |
| Region | GRCh38_6:8435568-9294133 |
| Ensemble | ENSG00000251164 |
| Refseq | NR_004855 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | Microarray, qPCR, RNAi, Northern blot, ISH etc. |
| Sample | HCC tissues, blood |
| Expression Pattern | up-regulated |
| Function Description | Nevertheless, these results demonstrate a highly specific up-regulation of HULC RNA expression levels in HCC. In situ hybridization revealed the specific and strong expression of HULC RNA in the cytoplasm of HCC, whereas it was not detected in tumor stroma and non-neoplastic liver cells. Because HULC was detected in blood of HCC patients, a potential use as novel biomarker can be envisaged. |
| Pubmed ID | 17241883 |
| Year | 2007 |
| Title | Characterization of HULC, a novel gene with striking up-regulation in hepatocellular carcinoma, as noncoding RNA. |
External Links
| Links for HULC | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |