Basic Information
| LncRNA/CircRNA Name | HULC |
| Synonyms | HULC, HCCAT1, LINC00078, NCRNA00078 |
| Region | GRCh38_6:8435568-9294133 |
| Ensemble | ENSG00000251164 |
| Refseq | NR_004855 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, RNAi, Western blot, Cell proliferation assay etc. |
| Sample | cell lines (HepG2, SNU-449, and SK-Hep-1) |
| Expression Pattern | up-regulated |
| Function Description | Sp1, Sp3 and Sp4 transcription factors regulate HULC and other lncRNAs in HCC cells. Sp proteins and HULC regulate HCC cell proliferation, survival, migration/invasion. Knockdown of Sp1 and HULC inhibit HCC cancer cell migration and invasion |
| Pubmed ID | 26317792 |
| Year | 2015 |
| Title | Specificity protein (Sp) transcription factors and metformin regulate expression of the long non-coding RNA HULC. |
External Links
| Links for HULC | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |