Basic Information
| LncRNA/CircRNA Name | HULC |
| Synonyms | HULC, HCCAT1, LINC00078, NCRNA00078 |
| Region | GRCh38_6:8435568-9294133 |
| Ensemble | ENSG00000251164 |
| Refseq | NR_004855 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | liver cancer |
| ICD-0-3 | C22.0 |
| Methods | qPCR, Western blot, Luciferase reporter assay etc. |
| Sample | liver cancer tissues, cell lines (CREB, HULC, Prkacb etc.) |
| Expression Pattern | up-regulated |
| Function Description | The study elucidates that fine tuning of HULC expression is part of an auto-regulatory loop in which it's inhibitory to expression and activity of miR-372 allows lncRNA up-regulated expression in liver cancer. |
| Pubmed ID | 20423907 |
| Year | 2010 |
| Title | CREB up-regulates long non-coding RNA, HULC expression through interaction with microRNA-372 in liver cancer. |
External Links
| Links for HULC | GenBank HGNC NONCODE |
| Links for liver cancer | OMIM COSMIC |