Basic Information
| LncRNA/CircRNA Name | HULC |
| Synonyms | HULC, HCCAT1, LINC00078, NCRNA00078 |
| Region | GRCh38_6:8435568-9294133 |
| Ensemble | ENSG00000251164 |
| Refseq | NR_004855 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qPCR, Cell viability assay, Colony formation assay etc. |
| Sample | glioma tissues, cell lines (SHG44, U251, and U87) |
| Expression Pattern | up-regulated |
| Function Description | HULC was highly expressed in glioma tissues, being closely related to age and grade of glioma. Functionally, forced expression of HULC results in increased cell proliferation and colony formation of U87 glioma cell line, whereas knockdown of HULC expression reduced these oncogenic properties of glioma cells. |
| Pubmed ID | 28053545 |
| Year | 2016 |
| Title | High expression of long noncoding RNA HULC is a poor predictor of prognosis and regulates cell proliferation in glioma. |
External Links
| Links for HULC | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |