Basic Information
| LncRNA/CircRNA Name | HULC |
| Synonyms | HULC, HCCAT1, LINC00078, NCRNA00078 |
| Region | GRCh38_6:8435568-9294133 |
| Ensemble | ENSG00000251164 |
| Refseq | NR_004855 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | pancreatic cancer |
| ICD-0-3 | C25 |
| Methods | qPCR, RNAi etc. |
| Sample | pancreatic cancer tissues, cell lines (MIAPace-2, CFPAC-1, PANC-1, AsPC-1 etc.) |
| Expression Pattern | up-regulated |
| Function Description | The higher expression of HULC was significantly correlated with large tumor size, advanced lymph node metastasis and vascular invasion. Multivariate analyses revealed that HULC expression served as an independent predictor for overall survival. Further experiments revealed that HULC knockdown significantly repressed cell proliferation of PC in vitro. |
| Pubmed ID | 25412939 |
| Year | 2014 |
| Title | Long noncoding RNA HULC is a novel biomarker of poor prognosis in patients with pancreatic cancer. |
External Links
| Links for HULC | GenBank HGNC NONCODE |
| Links for pancreatic cancer | OMIM COSMIC |