Basic Information
| LncRNA/CircRNA Name | HULC |
| Synonyms | NA |
| Region | GRCh38_6:8435568-9294133 |
| Ensemble | ENSG00000251164 |
| Refseq | NR_004855 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colon cancer |
| ICD-0-3 | C18 |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown, etc. |
| Sample | colon cancer tissues, Normal human colon cells, including HIEC, FHC and NCM460, human colon cancer cell lines (GEO, SNU-C1, Colo205, HCT-116, HT-29 and SW480) |
| Expression Pattern | up-regulated |
| Function Description | lncRNA-HULC was markedly increased in colon cancer cell lines and accelerated colon cancer cell growth by targeting miR-613.?HULC knockdown suppressed the proliferation, DNA synthesis and metastasis of human colon cancer cells in vitro.?Additionally, the modulation of rhotekin (RTKN) by miR-613 was necessary in HULC-induced colon cancer cell proliferation and metastasis.?The findings in the study suggested that HULC might inhibit the tumor growth through miR-613 dependent RTKN modulation. |
| Pubmed ID | 30551459 |
| Year | 2019 |
| Title | Long non-coding RNA HULC interacts with miR-613 to regulate colon cancer growth and metastasis through targeting RTKN. |
External Links
| Links for HULC | GenBank HGNC NONCODE |
| Links for colon cancer | OMIM COSMIC |