Basic Information
| LncRNA/CircRNA Name | HULC |
| Synonyms | NA |
| Region | GRCh38_6:8435568-9294133 |
| Ensemble | ENSG00000251164 |
| Refseq | NR_004855 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | geniposide(GEN) | |
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Western blot |
| Sample | gastric cancer tissues, cell lines (MKN45, SGC-7901, MKN28, AGS) |
| Expression Pattern | up-regulated |
| Function Description | The expression of HULC was up-regulated both in GC tissue and cell lines. GEN decreased cell viability (P<.05), colony formation (P????01), migration (P????05) and invasion (P????05) while HULC overexpression led to the opposite results in GEN-treated cells. In the current result, the cell survival fraction was significantly increased by transfection with pc-HULC compared with transfection with pcDNA3.1 .GEN inhibited cell proliferation and colony formation andinduced cell apoptosisby down-regulation of HULC. |
| Pubmed ID | 30176223 |
| Year | 2018 |
| Title | Geniposide suppresses growth, migration and invasion of MKN45 cells by down-regulation of lncRNA HULC. |
External Links
| Links for HULC | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |