malignant melanoma tissues, cell lines (B16, A375 and A2508, HEMn)
lncRNA HOXD-AS1 expression was remarkably higher in melanoma tissues. Increased expression of lncRNA HOXD-AS1 correlated with poor survival of melanoma patients.upregulated lncRNA HOXD-AS1 expression dramatically promoted cell proliferation and invasion of melanoma. lncRNA HOXD-AS1 knockdown notably reduced tumor growth.lncRNA HOXD-AS1 could epigenetically suppress the expression of RUNX3 via binding to EZH2. Downregulation of RUNX3 attenuated the proliferation and invasion-inhibiting effects induced by lncRNA HOXD-AS1 knockdown in melanoma cells.