Basic Information
| LncRNA/CircRNA Name | HULC |
| Synonyms | NA |
| Region | GRCh38_6:8435568-9294133 |
| Ensemble | ENSG00000251164 |
| Refseq | NR_004855 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | ETV and LdT | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, Western blot |
| Sample | HCC tissues,HBV-infected cell lines(PHH, HepG2-NTCP and dHepaRG) |
| Expression Pattern | up-regulated |
| Function Description | Long noncoding RNA HULC is identified and highly expressed in hepatocellular carcinoma (HCC).HULC significantly up-regulated microRNA-539, which targeted the 3??TR of APOBEC3B mRNA. |
| Pubmed ID | 30981758 |
| Year | 2019 |
| Title | Long non-coding RNA HULC activates HBV by modulating HBx/STAT3/miR-539/APOBEC3B signaling in HBV-related hepatocellular carcinoma. |
External Links
| Links for HULC | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |