Basic Information
| LncRNA/CircRNA Name | ANCR |
| Synonyms | DANCR, AGU2, ANCR, KIAA0114, SNHG13, lncRNA-ANCR |
| Region | GRCh38_4:52712404-52720351 |
| Ensemble | ENSG00000226950 |
| Refseq | NR_024031 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, Western blot, RIP, RNA pull-down assay, Cell proliferation assay etc. |
| Sample | breast cancer tissues, cell lines (MCF10A, MCF7, MDA-MB-231 and HEK293T) |
| Expression Pattern | down-regulated |
| Function Description | We also uncover ANCR is an important player in breast cancer progression and metastasis mainly through decreasing EZH2 stability. More specifically, we initially found that ANCR level was lower in breast cancer tissues and breast cancer cell lines, in contrast to their normal counterparts. We then demonstrated that knockdown of ANCR induced an EMT program and promoted cell migration and invasion in MCF10A (epithelial cells), whereas ectopic expression of ANCR repressed breast cancer cells migration and invasion. |
| Pubmed ID | 27716745 |
| Year | 2017 |
| Title | The degradation of EZH2 mediated by lncRNA ANCR attenuated the invasion and metastasis of breast cancer. |
External Links
| Links for ANCR | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |