Basic Information
| LncRNA/CircRNA Name | ANCR |
| Synonyms | DANCR, AGU2, ANCR, KIAA0114, SNHG13, lncRNA-ANCR |
| Region | GRCh38_4:52712404-52720351 |
| Ensemble | ENSG00000226950 |
| Refseq | NR_024031 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qPCR, RNAi etc. |
| Sample | glioma tissues, cell lines (NT2, U-87MG, A172, 1321N1, DAOY, Hela, HEK293T, Huh-7, SW480, KYSE, 5637 and AGS) |
| Expression Pattern | up-regulated |
| Function Description | Our qRT-PCR results revealed a significant upregulation of ANCR in more malignant and less differentiated types of brain tumors (P=0.03). This data was in accordance with down regulation of ANCR during neural differentiation. ANCR suppression caused an elevation in apoptosis rate, as well as a G1 cell cycle arrest in glioblastoma cell line. Altogether, our data demonstrated that ANCR may play a role in glioma genesis and that it could be considered as a potential diagnostic and therapeutic target to combat brain cancers. |
| Pubmed ID | 29476310 |
| Year | 2018 |
| Title | Anti-differentiation non-coding RNA, ANCR, is differentially expressed in different types of brain tumors. |
External Links
| Links for ANCR | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |