Basic Information
LncRNA/CircRNA Name | HOXD-AS1 |
Synonyms | HAGLR, HOXD-AS1, Mdgt |
Region | GRCh38_2:176164051-176188958 |
Ensemble | ENSG00000224189 |
Refseq | NR_033979 |
Classification Information
Regulatory Mechanism | Biological Function | Clinical Application | |||
---|---|---|---|---|---|
TF | Immune | Survival | |||
Enhancer | Apoptosis | Drug | |||
Variant | Cell Growth | Circulating | |||
MiRNA | EMT | Metastasis | |||
Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
Cancer Name | bladder cancer |
ICD-0-3 | C67 |
Methods | qPCR, RNAi, Cell proliferation assay etc. |
Sample | bladder cancer tissues, cell lines (5637, T24 etc.) |
Expression Pattern | up-regulated |
Function Description | We found that the expression level of HOXD-AS1 was significantly increased in bladder cancer tissues and cells. Furthermore, high expression of HOXD-AS1 was significantly related to tumor size, histological grade and TNM stage. In vitro assays confirmed that knockdown of HOXD-AS1 suppressed cell proliferation/migration and increased the rate of apoptotic cell in bladder cancer cells. At last, we used the important element of synthetic biology, tetracycline(tet)-controllable switch, to construct tet-controllable shRNA vectors which can modulate the expression of HOXD-AS1 in a dosage-dependent manner. |
Pubmed ID | 27328915 |
Year | 2016 |
Title | Synthetic tetracycline-controllable shRNA targeting long non-coding RNA HOXD-AS1 inhibits the progression of bladder cancer. |
External Links
Links for HOXD-AS1 | GenBank HGNC NONCODE |
Links for bladder cancer | OMIM COSMIC |