Basic Information
| LncRNA/CircRNA Name | HOXD-AS1 |
| Synonyms | HAGLR, HOXD-AS1, Mdgt |
| Region | GRCh38_2:176164051-176188958 |
| Ensemble | ENSG00000224189 |
| Refseq | NR_033979 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | melanoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, RIP |
| Sample | malignant melanoma tissues, cell lines (B16, A375 and A2508, HEMn) |
| Expression Pattern | up-regulated |
| Function Description | lncRNA HOXD-AS1 expression was remarkably higher in melanoma tissues. Increased expression of lncRNA HOXD-AS1 correlated with poor survival of melanoma patients.upregulated lncRNA HOXD-AS1 expression dramatically promoted cell proliferation and invasion of melanoma. lncRNA HOXD-AS1 knockdown notably reduced tumor growth.lncRNA HOXD-AS1 could epigenetically suppress the expression of RUNX3 via binding to EZH2. Downregulation of RUNX3 attenuated the proliferation and invasion-inhibiting effects induced by lncRNA HOXD-AS1 knockdown in melanoma cells. |
| Pubmed ID | 29312805 |
| Year | 2017 |
| Title | LncRNA HOXD-AS1 promotes melanoma cell proliferation and invasion by suppressing RUNX3 expression. |
External Links
| Links for HOXD-AS1 | GenBank HGNC NONCODE |
| Links for melanoma | OMIM COSMIC |