Basic Information
| LncRNA/CircRNA Name | HOXD-AS1 |
| Synonyms | HAGLR, HOXD-AS1, Mdgt |
| Region | GRCh38_2:176164051-176188958 |
| Ensemble | ENSG00000224189 |
| Refseq | NR_033979 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | qRT-PCR, Western blot, Luciferase reporter assay, in vitro knockdown, RIP |
| Sample | OC tissues, OC cell lines (Caov-3, SK-OV-3 and OVCAR-3) |
| Expression Pattern | up-regulated |
| Function Description | HOXD-AS1 was observed to be upregulated in both OC tissues and cell lines.HOXD-AS1 was detected to positively regulate the expression of frizzled family receptor 4 (FZD4) by competitively binding to miR-608. |
| Pubmed ID | 29416930 |
| Year | 2018 |
| Title | HOXD-AS1 promotes cell proliferation, migration and invasion through miR-608/FZD4 axis in ovarian cancer. |
External Links
| Links for HOXD-AS1 | GenBank HGNC NONCODE |
| Links for ovarian cancer | OMIM COSMIC |