Basic Information
LncRNA/CircRNA Name | HOXD-AS1 |
Synonyms | HAGLR, HOXD-AS1, Mdgt |
Region | GRCh38_2:176164051-176188958 |
Ensemble | ENSG00000224189 |
Refseq | NR_033979 |
Classification Information
Regulatory Mechanism | Biological Function | Clinical Application | |||
---|---|---|---|---|---|
TF | Immune | Survival | |||
Enhancer | Apoptosis | Drug | |||
Variant | Cell Growth | Circulating | |||
MiRNA | EMT | Metastasis | |||
Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
Cancer Name | neuroblastoma |
ICD-0-3 | NA |
Methods | Microarray, qPCR, RNAi, Northern blot etc. |
Sample | cell line (SH-SY5Y) |
Expression Pattern | up-regulated |
Function Description | One of these lncRNAs, termed HOXD-AS1, is encoded in HOXD cluster. HOXD-AS1 is overexpressed in neuroblastoma. We found that HOXD-AS1 is a subjetc to morphogenic regulation, is activated by PI3K/Akt pathway and itself is involved in control of RA-induced cell differentiation. Knock-down experiments revealed that HOXD-AS1 controls expression levels of clinically significant protein-coding genes involved in angiogenesis and inflammation, the hallmarks of metastatic cancer. |
Pubmed ID | 25522241 |
Year | 2014 |
Title | HOXD-AS1 is a novel lncRNA encoded in HOXD cluster and a marker of neuroblastoma progression revealed via integrative analysis of noncoding transcriptome. |
External Links
Links for HOXD-AS1 | GenBank HGNC NONCODE |
Links for neuroblastoma | OMIM COSMIC |