Basic Information
| LncRNA/CircRNA Name | HOXC-AS3 |
| Synonyms | NA |
| Region | GRCh38_12:53981509-53985519 |
| Ensemble | ENSG00000251151 |
| Refseq | NR_047506 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioblastoma |
| ICD-0-3 | NA |
| Methods | qRT-PCR, Western blotting, in vitro knockdown etc. |
| Sample | six GBM specimens and three adjacent normal brain tissues??Human-derived GBM cell lines U87, U251, and human brain cell line HEB |
| Expression Pattern | up-regulated |
| Function Description | HOXB13 was highly expressed in GBM tissues. Furthermore, we showed that high-level expression of HOXB13 in GBM was associated with worse survival, suggesting that HOXB13 could be a prognostic marker for patients with GBM. GBM cells U87 and U251 overexpressing HOXB13 showed enhanced proliferation, migration, and invasion relative to the control cells, while knockdown of HOXB13 led to decreased cell proliferation, migration, and invasion abilities. In addition, dual-luciferase report assay, chromatin immunoprecipitation assay, and quantitative real-time polymerase chain reaction data showed that HOXB13 directly bound to HOXC-AS3 promoter. HOXC-AS3 was involved in HOXB13-induced proliferation, migration, and invasion of GBM cells. |
| Pubmed ID | 31062400 |
| Year | 2019 |
| Title | HOXB13 promotes proliferation, migration, and invasion of glioblastoma through transcriptional upregulation of lncRNA HOXC-AS3 |
External Links
| Links for HOXC-AS3 | GenBank HGNC NONCODE |
| Links for glioblastoma | OMIM COSMIC |