Basic Information
| LncRNA/CircRNA Name | HOXC-AS3 |
| Synonyms | NA |
| Region | GRCh38_12:53981509-53985519 |
| Ensemble | ENSG00000251151 |
| Refseq | NR_047506 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | invasive mucinous adenocarcinoma |
| ICD-0-3 | NA |
| Methods | qRT-PCR, Western blot assay, RIP |
| Sample | IMA cell lines (A549, SPC-A1, NCI-H441, NCI-H1299) and a normal bronchial epithelial cell line HBE |
| Expression Pattern | up-regulated |
| Function Description | HOXC-AS3 was highly expressed in IMA cells. Additionally, it was identified that the significant down-regulation of HOXC-AS3 obstructed cell proliferation and migration in IMA. As far as mechanism is concerned, it found that HOXC-AS3 recruited FUS to stabilize FOXM1 mRNA, accelerating IMA progression. |
| Pubmed ID | 31925650 |
| Year | 2020 |
| Title | Long Noncoding RNA HOXC-AS3 Facilitates the Progression of Invasive Mucinous Adenocarcinomas of the Lung via Modulating FUS/FOXM1 |
External Links
| Links for HOXC-AS3 | GenBank HGNC NONCODE |
| Links for invasive mucinous adenocarcinoma | OMIM COSMIC |