Basic Information
| LncRNA/CircRNA Name | HOXC-AS3 |
| Synonyms | NA |
| Region | GRCh38_12:53981509-53985519 |
| Ensemble | ENSG00000251151 |
| Refseq | NR_047506 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, Luciferase reporter assay etc |
| Sample | breast cancer tissues,cell lines (MCF10A, MDA-MB-231, MCF-7,T47D, HCC-1954, SK-BR-3, and MDA-MB-468) |
| Expression Pattern | up-regulated |
| Function Description | HOXC-AS3 is aberrantly overexpressed in breast cancers especially the HER2+ type. Moreover, high expression of HOXC-AS3 has a relationship with poor clinical outcomes of breast cancer. In addition, HOXC-AS3 regulates cell Invasion and migration both in vitro and in vivo. Our results demonstrated that miR-3922-5p was a direct target of HOXC-AS3, and PPP1R1A was a target of miR-3922-5p in breast cance |
| Pubmed ID | 31797701 |
| Year | 2019 |
| Title | A Novel lncRNA HOXC-AS3 Acts as a miR-3922-5p Sponge to Promote Breast Cancer Metastasis |
External Links
| Links for HOXC-AS3 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |