Basic Information
| LncRNA/CircRNA Name | HOXC-AS1 |
| Synonyms | HOXC cluster antisense RNA 1 |
| Region | GRCh38_12:53999022-54000010 |
| Ensemble | ENSG00000250451 |
| Refseq | NR_047504 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | Microarray, qRT-PCR, Western blot, Luciferase reporter assay, RIP |
| Sample | GC tissues,stomach cell (GES-1), GC cells (MKN45, MKN28, MGC803, BGC-823 and AGS) and human embryonic kidney cell (HEK-293??) |
| Expression Pattern | up-regulated |
| Function Description | HOXC-AS1 was discovered to be upregulated in GC and located both in cytoplasm and in nucleus in GC cells. Functionally, inhibition of HOXC-AS1 restrained GC cell growth and metastasis both in vitro and in vivo.HOXC-AS1 positively regulated MYC expression in GC through targeting miR-590-3p/MYC axis in cytoplasm and modulating BRG1/?-catenin complex-activated MYC transcription in nucleus. |
| Pubmed ID | 31870402 |
| Year | 2019 |
| Title | HOXC-AS1-MYC Regulatory Loop Contributes to the Growth and Metastasis in Gastric Cancer |
External Links
| Links for HOXC-AS1 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |