Basic Information
| LncRNA/CircRNA Name | HOXC13-AS |
| Synonyms | NA |
| Region | GRCh38_12:53935328-53939643 |
| Ensemble | ENSG00000249641 |
| Refseq | NR_047507 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qRT-PCR , Luciferase reporter assay , Western blot , in vitro knockdown etc. |
| Sample | breast cancer tissues and adjacent normal tissues ,breast cancer cell lines (MCF7 and MDA-MB-468) |
| Expression Pattern | up-regulated |
| Function Description | HOXC13-AS was increased in breast cancer tissues compared with the adjacent normal tissues and upregulated HOXC13-AS promoted the growth of breast cancer cells.miR-497-5p levels were downregulated in cancer tissues compared with the adjacent tissues and miR-497-5p suppressed breast cancer cell proliferation.HOXC13-AS could function as a "sponge" for miR-497-5p then suppress miR-497-5p expression.HOXC13-AS promoted the proliferation of breast cancer cells and tumor growth through miR-497-5p/PTEN axis in vitro and in vivo. |
| Pubmed ID | 31066051 |
| Year | 2019 |
| Title | HOXC13-AS Promotes Breast Cancer Cell Growth Through Regulating miR-497-5p/PTEN Axis |
External Links
| Links for HOXC13-AS | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |