Basic Information
| LncRNA/CircRNA Name | HOXB-AS3 |
| Synonyms | HOXA6as |
| Region | GRCh38_7:27129977-27155928 |
| Ensemble | ENSG00000254369 |
| Refseq | NR_038831 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colon cancer |
| ICD-0-3 | C18 |
| Methods | qPCR, Western blot etc. |
| Sample | cell lines (SW480, SW620, HTC-116, MDA-MB-231, SK-OV-3, S18, S26, HEK293T) |
| Expression Pattern | down-regulated |
| Function Description | Here, we discovered that the lncRNA HOXB-AS3 encodes a conserved 53-aa peptide. The HOXB-AS3 peptide, not lncRNA, suppresses colon cancer (CRC) growth. Mechanistically, the HOXB-AS3 peptide competitively binds to the ariginine residues in RGG motif of hnRNP A1 and antagonizes the hnRNP A1-mediated regulation of pyruvate kinase M (PKM) splicing by blocking the binding of the ariginine residues in RGG motif of hnRNP A1 to the sequences flanking PKM exon 9, ensuring the formation of lower PKM2 and suppressing glucose metabolism reprogramming. CRC patients with low levels of HOXB-AS3 peptide have poorer prognoses. Our study indicates that the loss of HOXB-AS3 peptide is a critical oncogenic event in CRC metabolic reprogramming. |
| Pubmed ID | 28985503 |
| Year | 2017 |
| Title | A Peptide Encoded by a Putative lncRNA HOXB-AS3 Suppresses Colon Cancer Growth |
External Links
| Links for HOXB-AS3 | GenBank HGNC NONCODE |
| Links for colon cancer | OMIM COSMIC |