Basic Information
| LncRNA/CircRNA Name | HOXB-AS1 |
| Synonyms | HOXB cluster antisense RNA 1 |
| Region | GRCh38_17:48543551-48551250 |
| Ensemble | ENSG00000230148 |
| Refseq | NR_102279 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | multiple myeloma |
| ICD-0-3 | C42.1 |
| Methods | qRT-PCR, Western blot analysis, RIP |
| Sample | Tissue samples,plasma cells (nPCs) and four accepted MM cell lines (U1996, KM3, H929, and U266) |
| Expression Pattern | up-regulated |
| Function Description | HOXB-AS1 was highly expressed in MM and loss-of-function assays certified that HOXB-AS1 obstruction suppressed MM cell proliferation, and stimulated cell apoptosis. In addition, HOXB-AS1 could modulate fucosyltransferase 4 (FUT4) and FUT4-mediated Wnt/?-catenin pathway. In subsequence, it was observed from mechanism assays that HOXB-AS1 enhanced the interaction between ELAVL1 and FUT4 so as to stabilize FUT4 messenger RNA. In the end, rescue experiments affirmed that HOXB-AS1 affected the cell growth through FUT4 in MM. |
| Pubmed ID | 31886581 |
| Year | 2019 |
| Title | LncRNA HOXB-AS1 Promotes Cell Growth in Multiple Myeloma via FUT4 mRNA Stability by ELAVL1 |
External Links
| Links for HOXB-AS1 | GenBank HGNC NONCODE |
| Links for multiple myeloma | OMIM COSMIC |