Basic Information
| LncRNA/CircRNA Name | HOXB13-AS1 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, ChIP, RIP |
| Sample | glioma tissues, cell lines (U251, U87, SHG-44, SHG139, NHA) |
| Expression Pattern | up-regulated |
| Function Description | We showed that HOXB13-AS1 was significantly upregulated in glioma tissues and cells and was negatively correlated with its surrounding gene HOXB13 levels. Functional experiments in vitro and in vivo revealed that high level of HOXB13-AS1 increased cell proliferation and tumor growth by promoting cell cycle progression.we showed that HOXB13-AS1 overexpression increased DNMT3B-mediated methylation of adjacent gene HOXB13 promoter by binding with the enhancer of zeste homolog 2 (EZH2) using bisulfite sequencing PCR (BSP), epigenetically suppressing HOXB13 expression. |
| Pubmed ID | 30105866 |
| Year | 2018 |
| Title | Long noncoding RNA HOXB13-AS1 regulates HOXB13 gene methylation by interacting with EZH2 in glioma. |
External Links
| Links for HOXB13-AS1 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |