Basic Information
| LncRNA/CircRNA Name | HOXA6-HOXA5 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colon cancer |
| ICD-0-3 | C18 |
| Methods | qPCR , Western blot , RNAi , in vitro knockdown etc. |
| Sample | colon cancer tissues ,human colon cancer cell lines HCT116, DLD1C), and HT-29 ,human lung cell lines( A549 and BEAS-2B) ,Human colonic epithelial cells (HCEC-1CT) |
| Expression Pattern | up-regulated |
| Function Description | Expression of HOXA5 short RNA was upregulated in advanced colon cancer tissues.HOXA5 short RNA preferentially modified expression of epidermal growth factor (EGF) signal-related genes.stable overexpression of HOXA5 short RNA increased EGF receptor levels and facilitated its phosphorylation in both HCT116 cells and xenograft tumors.Knockdown of HOXA5 long 1 and long 2 transcripts did not affect cell growth, while selective silencing of HOXA5 short RNA inhibited cell growth independent of HOXA5 expression.Stable overexpression of HOXA5 short RNA promoted proliferation and migration of colon cancer cell lines HCT116, DLD1, and HT-29 and accelerated tumor growth in the xenograft mouse model. |
| Pubmed ID | 31159758 |
| Year | 2019 |
| Title | A Novel Long Non-Coding RNA From the HOXA6-HOXA5 Locus Facilitates Colon Cancer Cell Growth |
External Links
| Links for HOXA6-HOXA5 | GenBank HGNC NONCODE |
| Links for colon cancer | OMIM COSMIC |