Basic Information
| LncRNA/CircRNA Name | HOXA11-AS |
| Synonyms | HOXA11-AS, HOXA-AS5, HOXA11-AS1, HOXA11AS, HOXA11S, NCRNA00076 |
| Region | GRCh38_7:27184518-27189293 |
| Ensemble | ENSG00000240990 |
| Refseq | NR_002795 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, Western blot etc. |
| Sample | hepatocellular carcinoma tissues, cell lines(Hep3B, SMMC-7721, MHCC97-H, BEL-7402 and HL-7702) |
| Expression Pattern | up-regulated |
| Function Description | HOXA11-AS expression was up-regulated in the HCC tissues,and the higher expression of HOXA11-AS was associated with the advanced stage in the HCC samples. In addition,the expression of HOXA11-AS was up-regulated in HCC cell lines compared with normal liver cell lines. Ectopic expression of miR-214-3p suppressed HCC cell proliferation and invasion.Furthermore,we indicated that overexpression of HOXA11-AS decreased the miR-214-3p expression and the expression of miR-214-3p was negatively related with the HOXA11-AS expression in HCC samples. Ectopic expression of HOXA11-AS increased HCC proliferation and invasion and induced EMT through inhibiting miR-214-3p expression.These data suggested that HOXA11-AS/miR-214-3p axis was responsible for development of HCC.We ndemonstrated that miR-214-3p expression was down-regulated in the HCC tissues and the expression of miR-214-3p was negatively correlated with the expression of HOXA11-AS. |
| Pubmed ID | 29761918 |
| Year | 2018 |
| Title | LncRNA HOXA11-AS promotes hepatocellular carcinoma progression by repressing miR-214-3p. |
External Links
| Links for HOXA11-AS | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |