Basic Information
| LncRNA/CircRNA Name | HOXA11-AS |
| Synonyms | HOXA11-AS, HOXA-AS5, HOXA11-AS1, HOXA11AS, HOXA11S, NCRNA00076 |
| Region | GRCh38_7:27184518-27189293 |
| Ensemble | ENSG00000240990 |
| Refseq | NR_002795 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | Microarray, qPCR, Western blot etc. |
| Sample | cell lines (HepG2, Hep3B, Bel-7402, SMMC-7721 ) |
| Expression Pattern | down-regulated |
| Function Description | lncRNA HOXA11-AS could promote the proliferation of HCC cells by recruiting EZH2 and suppressing the expression of the tumor suppressor DUSP5. LncRNA-HOXA11-AS is correlated with the clinicopathological features and overall survival of HCC patients. |
| Pubmed ID | 29312625 |
| Year | 2017 |
| Title | Long non-coding RNA HOXA11-AS promotes the proliferation HCC cells by epigenetically silencing DUSP5 |
External Links
| Links for HOXA11-AS | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |