Basic Information
| LncRNA/CircRNA Name | HOXA11-AS |
| Synonyms | HOXA11-AS, HOXA-AS5, HOXA11-AS1, HOXA11AS, HOXA11S, NCRNA00076 |
| Region | GRCh38_7:27184518-27189293 |
| Ensemble | ENSG00000240990 |
| Refseq | NR_002795 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | qPCR, RNAi, Western blot, Cell proliferation assay etc. |
| Sample | cervical cancer tissues, cell lines (SiHa, HeLa, CaSki, ME-180 and C33A) |
| Expression Pattern | up-regulated |
| Function Description | HOXA11-AS expression was significantly greater in tissues from patients with cervical cancer than in control patients. HOXA11-AS overexpression enhanced cell proliferation, migration, and tumor invasion in vitro, whereas HOXA11-AS knockdown inhibited these biologic aggressive features. In vivo xenograft experiments using the siHOXA11-AS-transfected HeLa cells revealed that HOXA11-AS strongly induced tumor growth. Furthermore, we found that HOXA11-AS knockdown decreased cancer stemness and triggered the EMT program. |
| Pubmed ID | 27792998 |
| Year | 2016 |
| Title | The long noncoding RNA HOXA11 antisense induces tumor progression and stemness maintenance in cervical cancer. |
External Links
| Links for HOXA11-AS | GenBank HGNC NONCODE |
| Links for cervical cancer | OMIM COSMIC |