Basic Information
| LncRNA/CircRNA Name | HOXA11-AS |
| Synonyms | HOXA11-AS, HOXA-AS5, HOXA11-AS1, HOXA11AS, HOXA11S, NCRNA00076 |
| Region | GRCh38_7:27184518-27189293 |
| Ensemble | ENSG00000240990 |
| Refseq | NR_002795 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | RNA-seq, Microarray, qPCR, Cell transfection, Western blot, RIP, ChIP, Luciferase reporter assay etc. |
| Sample | gastric cancer tissues |
| Expression Pattern | up-regulated |
| Function Description | In vitro and in vivo assays of HOXA11-AS alterations revealed a complex integrated phenotype affecting cell growth, migration, invasion, and apoptosis. Mechanistically, EZH2 along with the histone demethylase LSD1 or DNMT1 were recruited by HOXA11-AS, which functioned as a scaffold. HOXA11-AS also functioned as a molecular sponge for miR-1297, antagonizing its ability to repress EZH2 protein translation. In addition, we found that E2F1 was involved in HOXA11-AS activation in gastric cancer cells. |
| Pubmed ID | 27651312 |
| Year | 2016 |
| Title | LncRNA HOXA11-AS Promotes Proliferation and Invasion of Gastric Cancer by Scaffolding the Chromatin Modification Factors PRC2, LSD1, and DNMT1. |
External Links
| Links for HOXA11-AS | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |