Basic Information
| LncRNA/CircRNA Name | HOXA11-AS |
| Synonyms | HOXA11-AS, HOXA-AS5, HOXA11-AS1, HOXA11AS, HOXA11S, NCRNA00076 |
| Region | GRCh38_7:27184518-27189293 |
| Ensemble | ENSG00000240990 |
| Refseq | NR_002795 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot etc. |
| Sample | OS tissues, cell lines (U2OS, MG-63 and KHOS) |
| Expression Pattern | up-regulated |
| Function Description | the expression of HOXA11-AS was upregulated in OS tissues and cell lines.The high expression of HOXA11-AS was associated with advanced clinical stage, distant metastasis and poor overall survival of OS. HOXA11-AS silencing suppressed OS cells proliferation, invasion and induced cell arrest in G0/G1 phase. HOXA11-AS acts as an endogenous sponge by directly binding miR-124-3p,and decreasing the xpression of miR-124-3p.HOXA11-AS may regulate tumor progression by affecting miR-124-3p targets, and ROCK1 expression. |
| Pubmed ID | 28558357 |
| Year | 2017 |
| Title | Long non-coding RNA HOXA11-AS functions as a competing endogenous RNA to regulate ROCK1 expression by sponging miR-124-3p in osteosarcoma. |
External Links
| Links for HOXA11-AS | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |