Basic Information
| LncRNA/CircRNA Name | HOXA11-AS |
| Synonyms | HOXA11-AS, HOXA-AS5, HOXA11-AS1, HOXA11AS, HOXA11S, NCRNA00076 |
| Region | GRCh38_7:27184518-27189293 |
| Ensemble | ENSG00000240990 |
| Refseq | NR_002795 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | uveal melanoma |
| ICD-0-3 | C69.9 |
| Methods | qPCR, Western blot, Luciferase reporter assay etc. |
| Sample | cell lines (OCM-1A, MUM-2C, C918, MUM-2B, D78) |
| Expression Pattern | up-regulated |
| Function Description | The aim of this study was to explore the critical role of lncRNA HOXA11-AS in uveal melanoma (UM) progression.Briefly, we found that HOXA11-AS is overexpressed in UM tissues and cells; HOXA11-AS could regulate UM cell growth, invasion, and apoptosis. Mechanistically, RNA immunoprecipitation demonstrated that HOXA11-AS could simultaneously interact with enhancer of zeste homolog 2 (EZH2) to suppress its target p21 protein expression. In addition, we demonstrated that HOXA11-AS functioned as a molecular sponge for miR-124, and overexpression of miR-124 attenuated the proliferation and invasion-promoting effect of HOXA11-AS. Collectively, our findings reveal an oncogenic role for HOXA11-AS in UM tumorigenesis. |
| Pubmed ID | 28749709 |
| Year | 2017 |
| Title | LncRNA HOXA11-AS Exerts Oncogenic Functions by Repressing p21 and miR-124 in Uveal Melanoma |
External Links
| Links for HOXA11-AS | GenBank HGNC NONCODE |
| Links for uveal melanoma | OMIM COSMIC |