Basic Information
| LncRNA/CircRNA Name | HOXA11-AS |
| Synonyms | NA |
| Region | GRCh38_7:27184518-27189293 |
| Ensemble | ENSG00000240990 |
| Refseq | NR_002795 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | oral squamous cell carcinoma |
| ICD-0-3 | C06.9 |
| Methods | qRT-PCR, Western blot analysis etc. |
| Sample | OSCC tissues and adjacent paraneoplastic tissues ,normal human oral keratinocytes (NHOK) cell lines and OSCC cell lines(HN5, CAL-27, Tca8113, SCC-9, SCC-15 and SCC-25) |
| Expression Pattern | up-regulated |
| Function Description | HOXA11-AS signifcantly promotes cell proliferation, reduces the percentage of G0/G1 phase cells and enhances the cell invasion in OSCC. Bioinformatics analysis suggested that a microRNA (miRNA), miR-518a-3p, is as a target of HOXA11-AS. Alteration of miR-518a-3p levels by HOXA11-AS transduced to changes in PDK1 expression. In a mouse model of OSCC, HOXA11-AS overexpression promoted tumor growth, concomitant with reduced miR-518a-3p expression and increased PDK1 expression |
| Pubmed ID | 31139017 |
| Year | 2019 |
| Title | HOXA11-AS Promotes the Progression of Oral Squamous Cell Carcinoma by Targeting the miR-518a-3p/PDK1 Axis |
External Links
| Links for HOXA11-AS | GenBank HGNC NONCODE |
| Links for oral squamous cell carcinoma | OMIM COSMIC |