Basic Information
| LncRNA/CircRNA Name | HOXA11-AS |
| Synonyms | NA |
| Region | GRCh38_7:27184518-27189293 |
| Ensemble | ENSG00000240990 |
| Refseq | NR_002795 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | propofol | |
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qRT-PCR , Luciferase reporter assay , Western blot etc. |
| Sample | cell lines(Colo205 and SW620) |
| Expression Pattern | down-regulated |
| Function Description | Propofol promoted cell apoptosis and inhibited cell proliferation in both Colo205 and SW620 cells, through the down-regulation of HOXA11-AS and up-regulation of let-7i.Moreover, a negative correlation between HOXA11-AS and let-7i in propofol-mediated biological functions of CRC cells.Furthermore, HOXA11-AS acts as a molecular sponge for let-7i, thereby regulating the expression of ABCC10. |
| Pubmed ID | 31013434 |
| Year | 2019 |
| Title | Propofol Promotes Apoptosis of Colorectal Cancer Cells via Alleviating the Suppression of lncRNA HOXA11-AS on miRNA let-7i |
External Links
| Links for HOXA11-AS | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |