Basic Information
| LncRNA/CircRNA Name | HOXA11-AS |
| Synonyms | NA |
| Region | GRCh38_7:27184518-27189293 |
| Ensemble | ENSG00000240990 |
| Refseq | NR_002795 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | clear cell renal cell carcinoma |
| ICD-0-3 | C64.9 |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown, RIP |
| Sample | clear cell renal cell carcinoma tissues, cell lines(ACHN, 786-O, A498, and OSRC-2) |
| Expression Pattern | up-regulated |
| Function Description | The expression of HOXA11-AS was significantly upregulated in clear cell renal cell carcinoma (ccRCC) tissues and cell lines. High HOXA11-AS expression was associated with the advanced clinical stage, tumor stage, and lymph node metastasis. Function assays showed that HOXA11-AS inhibition significantly suppressed renal cancer cells growth, invasion, and ETM phenotype. In addition, underlying mechanism revealed that HOXA11-AS could act as a competing endogenous RNA (ceRNA) that repressed miR-146b-5p expression, which regulated its downstream target MMP16 in renal cancer. Taken together, our findings suggested that HOXA11-AS could promote renal cancer cells growth and invasion by modulating miR-146b-5p-MMP16 axis. |
| Pubmed ID | 29953617 |
| Year | 2018 |
| Title | HOXA11-AS Promotes the Growth and Invasion of Renal Cancer by Sponging miR-146b-5p to Upregulate MMP16 Expression |
External Links
| Links for HOXA11-AS | GenBank HGNC NONCODE |
| Links for clear cell renal cell carcinoma | OMIM COSMIC |