Basic Information
| LncRNA/CircRNA Name | HOXA11-AS |
| Synonyms | NA |
| Region | GRCh38_7:27184518-27189293 |
| Ensemble | ENSG00000240990 |
| Refseq | NR_002795 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | oral squamous cell carcinoma |
| ICD-0-3 | C06.9 |
| Methods | qRT-PCR, Western blot, RIP |
| Sample | OSCC tissues,cell lines (SCC-15 and SCC-25) |
| Expression Pattern | up-regulated |
| Function Description | HOXA11-AS was highly expressed in OSCC tissues and cells.Knockdown of HOXA11-AS significantly reduced proliferation, migration, invasion and EMT, while promoted apoptosis of OSCC cells. |
| Pubmed ID | 31731187 |
| Year | 2020 |
| Title | LncRNA HOXA11-AS promotes OSCC progression by sponging miR-98-5p to upregulate YBX2 expression |
External Links
| Links for HOXA11-AS | GenBank HGNC NONCODE |
| Links for oral squamous cell carcinoma | OMIM COSMIC |